Some proteins present in snake venom possess enzymatic activities, such as phospholipase A(2) and l-aminoacid oxidase.
2
The peptide synthesized from L-aminoacids was rapidly degraded and excreted in the urine.
3
Potent and selective thrombin inhibitors have been prepared with a piperazinedione template and L-aminoacids.
4
LAAOcdt showed amino acid homology to other L-aminoacid oxidases isolated from different snake venoms.
5
Methods: The effects of the TJ-135 were examined using the choline-deficient L-aminoacid-defined diet-induced liver fibrosis model.
Ús de d-amino acid en anglès
1
Likewise, incorporation of D-aminoacids led to potent inhibitors with a novel mode of binding.
2
It activates D-aminoacid oxidase, which oxidizes D-serine, leading to modulation of the N-methyl-D-aspartate receptor.
3
Our previous studies have identified synthetic D-aminoacid cell adhesion peptides using a combinatorial screening approach.
4
Because this motif is sufficient for activity, an ShK analogue was designed based on D-aminoacids.
5
The purified enzyme catalyzed the dehydrogenation of various d-aminoacids, with d-phenylalanine being the most preferred substrate.
6
D-Aminoacid substitution was employed to search for novel AII antagonists that would also display reduced partial agonist activity.
7
This D-aminoacid cyclic peptide did not adopt a conformation homologous to the NGF C-D loop and was inactive.
8
N-terminal acetylation or incorporation of D-aminoacids in the GPGRAF sequence of this SPC resulted in significant loss of activity.
9
Overall, these results agree with the innovative therapeutic research in schizophrenia that is aimed at targeting glutamatergic transmission via D-aminoacids.
10
For example, younger animals have lower amounts of these oxidases and consequently higher concentrations of free D-aminoacids compared to adult animals.
11
In the liver and kidneys of the animals, an inverse relationship exists between the occurrence of D-aminoacids and these oxidative enzymes.
12
A specific enzyme induction for these D-aminoacid oxidases exists in young rats following ingestion of free D-amino acids by the mother.
13
Phylogenetic analyses of condensation domains indicated that N-terminal domains and domains that condense L-amino acids and D-aminoacids, respectively, form three separate groups.
14
If the ingested D-aminoacids are not metabolized by these enzymes, they will accumulate in the tissues and may provoke serious damage, e.g.
15
Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-aminoacid substitution, cyclization, replacement of labile aminos acids, etc.
16
When a peptide synthesized from D-aminoacids (D-4F) was administered orally to LDL receptor-null mice on a Western diet, lesions decreased by 79%.